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                             April 27, 2022

       Zheng Wei, Ph.D.
       Chief Executive Officer
       Connect Biopharma Holdings Limited
       Science and Technology Park
       East R&D Building, 3rd Floor
       6 Beijing West Road, Taicang
       Jiangsu, the People   s Republic of China 215400

                                                        Re: Connect Biopharma
Holdings Limited
                                                            Registration
Statement on Form F-3
                                                            Filed April 15,
2022
                                                            File No. 333-264340

       Dear Dr. Wei:

              We have limited our review of your registration statement to
those issues we have
       addressed in our comments. In some of our comments, we may ask you to
provide us with
       information so we may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.

       Registration Statement on Form F-3 filed April 15, 2022

       Cover Page

   1.                                                   Please provide
prominent disclosure here disclosing that you were provisionally identified
                                                        by the Commission on
April 12, 2022 under the HFCAA. Refer to

https://www.sec.gov/hfcaa. Please also revise your disclosure in the sales
agreement
                                                        prospectus accordingly.
 Zheng Wei, Ph.D.
FirstName   LastNameZheng   Wei, Ph.D.
Connect Biopharma    Holdings Limited
Comapany
April       NameConnect Biopharma Holdings Limited
       27, 2022
April 227, 2022 Page 2
Page
FirstName LastName
Our Company, page 3

2.       Prominently disclose each permission that you, or your subsidiaries
are required to obtain
         from Chinese authorities to operate and issue these securities to
foreign investors. State
         whether you or your subsidiaries are covered by permissions
requirements from the
         CSRC, CAC or any other entity that is required to approve of your or
your subsidiaries
         operations, and state affirmatively whether you have received all
requisite permissions
         and whether any permissions have been denied. Please also describe the
consequences to
         you and your investors if you or your subsidiaries: (i) do not receive
or maintain such
         permissions or approvals, (ii) inadvertently conclude that such
permissions or approvals
         are not required, or (iii) applicable laws, regulations, or
interpretations change and you are
         required to obtain such permissions or approvals in the future. Please
also revise your
         disclosure in the sales agreement prospectus accordingly.
3.       We note your disclosure on pages 3 and S-7 relating to the risk that
your securities may be
         prohibited from trading under the Holding Foreign Companies
Accountable Act as early
         as 2024 if the PCAOB is unable to inspect or fully investigate your
auditor. Please revise
         to clarify that if the PCAOB determines that it cannot inspect or
fully investigate your
         auditor, your securities could be prohibited from trading and that as
a result, an exchange
         may determine to delist your securities.
Cash Transfer and Dividend Payment, page 6

4.       Please update your disclosure to disclose if you have specific cash
management policies
         and procedures in place that dictate how funds are transferred through
your organization
         and if applicable, describe these policies and procedures in greater
detail. Please also
         revise your disclosure in the sales agreement prospectus accordingly.
Summary of Risk Factors, page 7

5.       In your summary of risk factors here and in your sales agreement
prospectus, specifically
         discuss risks arising from the legal system in China, including risks
and uncertainties
         regarding the enforcement of laws and that rules and regulations in
China can change
         quickly with little advance notice.
6.       We refer to your summary risk factor on pages 7 and S-8 that PRC
government agencies
         may exert more oversight and control over offerings that are conducted
overseas and non-
         PRC investment in PRC-based issuers. Please revise to specifically
acknowledge the risk
         that such oversight and control by the PRC government could
significantly limit or
         completely hinder your ability to offer or continue to offer
securities to investors and
         cause the value of such securities to significantly decline or be
worthless.
 Zheng Wei, Ph.D.
FirstName   LastNameZheng   Wei, Ph.D.
Connect Biopharma    Holdings Limited
Comapany
April       NameConnect Biopharma Holdings Limited
       27, 2022
April 327, 2022 Page 3
Page
FirstName LastName
Enforcement of Civil Liabilities, page 43

7.       Please expand your disclosure to specifically discuss whether you have
officers or
         directors located in China, and if so, address the difficulty of
bringing actions and
         enforcing judgments against individuals located in China. Please also
include relevant
         summary risk factor and risk factor disclosure, as applicable. Please
also revise your
         disclosure in the sales agreement prospectus accordingly.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       Please contact Jane Park at 202-551-7439 or Jason Drory at 202-551-8342
with any
questions.



                                                             Sincerely,

                                                             Division of
Corporation Finance
                                                             Office of Life
Sciences
cc:      Michael Sullivan, Esq.